Salivary Aβ-40, Aβ-42, IGF-I, IGF-II, Alpha Amylase, IL-1β, and TNF-alpha in Alzheimer's Disease: A Useful Diagnostic Tool
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چکیده
A very significant challenge in Alzheimer's disease today is the discovery of suitable technologies for detection of the disease that are easy to use, cost effective and non-invasive. In this study we demonstrate that saliva biomarkers are a suitable option for detection of the disease. Accordingly, we collected saliva samples by three different methods from age and gender matched Alzheimer's patients and normal healthy subjects. Salivary Aβ-40, Aβ-42, IGF-I, IGF-II, alpha amylase, IL-1β, and TNF-alpha levels were analyzed. Of the three methods, passive drooling was found to be the best saliva collection method for analysis of biomarkers of Alzheimer's disease. There were significant differences in the salivary biomarkers evaluated between patients and controls. Additional results from our studies confirm that Aβ-40, Aβ-42, IGF-I, IGF-II, alpha amylase, IL-1β, and TNF-alpha are appropriate diagnostic biomarkers for Alzheimer's disease.
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Correspondence: H Mina Tait Group X10, Western Bank, Sheffield, S10 2TN, UK Tel +44 011 4222 0000 Fax +44 011 4276 5413 Email [email protected] Dear editor Zhang et al have recently published an interesting article in Clinical Interventions in Aging entitled “Atorvastatin attenuates the production of IL-1β, IL-6, and TNF-α in the hippocampus of an amyloid β1-42-induced rat model of Alzhei...
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